ondansetron, 240 of 1846 (13.0%) received intravenous rehydration, and 67 of 1846 (3.6%) were hospitalized. rehydration therapy to reduce intravenous rehydration and the RESULTS This secondary analysis of 2 randomized clinical trials included 1846 children (mean hospitalization of children with age, 19.1 months 1007 boys ), of whom 534 of 1846 (28.9%) received oral gastroenteritis. Meaning These findings suggest that oral ondansetron may support oral MAIN OUTCOMES AND MEASURES Intravenous fluid administration and hospitalization.
Dehydration Scale score, oral ondansetron followed by oral rehydration therapy, and infectious agent. clinical dehydration score, care in the US, greater frequency of vomiting, and EXPOSURES Sex, age, preceding health care visit, distance between home and hospital, country lack of oral ondansetron were (US vs Canada), frequency and duration of vomiting and diarrhea, presence of fever, Clinical associated with hospitalization. Data were analyzed from November 2, 2018, to March and lack of oral ondansetron. Children were from 16 pediatric emergency departments vomiting, prior intravenous rehydration, throughout Canada (6) and the US (10). Participants include children aged 3 to 48 months with 3 or more watery score, care in the US relative to Canada, stools in 24 hours between November 5, 2013, and April 7, 2017, for the PERC study and July 8, 2014, greater frequency and duration of and June 23, 2017, for the PECARN Study. randomized clinical trials with 1846 children, independent variables DESIGN, SETTING, AND PARTICIPANTS This study is a planned secondary analysis of the Pediatric associated with intravenous rehydration Emergency Research Canada (PERC) and Pediatric Emergency Care Applied Research Network included a higher clinical dehydration (PECARN) probiotic trials. and hospitalization in children with acute gastroenteritis? OBJECTIVE To identify factors associated with intravenous fluid administration and hospitalization Findings In this secondary analysis of 2 in children with acute gastroenteritis. Key Points Question What clinical features are IMPORTANCE Despite guidelines endorsing oral rehydration therapy, intravenous fluids are associated with intravenous rehydration commonly administered to children with acute gastroenteritis in high-income countries. Gouin, Serge Vance, Cheryl Farion, Ken J.
Variables Associated With Intravenous Rehydration and Hospitalization in Children With Acute Gastroenteritis Variables Associated With Intravenous Rehydration and Hospitalization in Children With Acute.